ORA-00600: internal error code, arguments: [17281], [1001], [0x7000002286E6130],[], [], [], [], []
ORA-01001: invalid cursor[@more@]

You are seeing the following error message when running queries.:

ORA-00600: internal error code, arguments: [17281], [1001], [0x18E3EE690], [], [], [], [], []

You may or may not see this error message as well.:
ORA-01001: invalid cursor

Cause

This issue can be related to running SQL through TOAD.

You can check if TOAD was the client that resulted in the error from the processstate dump in the trace file, it will show:-

program: TOAD.exe / application name: TOAD.exe

Solution

Run the queries directly through SQLPLUS instead of using TOAD.

This may also be related to Bug 4359111, patches for this bug can be found on:-