Oracle 10.2.0.4 ,   Linux AS 5.3  64bit . 

Listener.ora 文件如下，配置应该没有错误： 

LISTENER =
  (DESCRIPTION_LIST =
    (DESCRIPTION =
      (ADDRESS_LIST = 
        (ADDRESS = (PROTOCOL = TCP)(HOST = 10.13.13.188)(PORT = 1526))
      )
      (ADDRESS_LIST =
        (ADDRESS = (PROTOCOL = IPC)(KEY = EXTPROC))
      )
    )
  )

SID_LIST_LISTENER =
  (SID_LIST =
    (SID_DESC =
      (SID_NAME = PLSExtProc)
      (ORACLE_HOME = /u01/product/oracle)
      (PROGRAM = extproc)
    )
   (SID_DESC =
      (GLOBAL_DBNAME = b2b)
      (ORACLE_HOME = /u01/product/oracle)
      (SID_NAME = b2b)
    )
  )

开启监听的时候报错 ：  

MXB2B-WEB01<*b2b*/home/oracle>$lsnrctl start

LSNRCTL for Linux: Version 10.2.0.4.0 - Production on 09-MAR-2010 13:53:34

Copyright (c) 1991, 2007, Oracle.  All rights reserved.

Starting /u01/product/oracle/bin/tnslsnr: please wait...

TNSLSNR for Linux: Version 10.2.0.4.0 - Production
System parameter file is /u01/product/oracle/network/admin/listener.ora
Log messages written to /u01/product/oracle/network/log/listener.log
Listening on: (DESCRIPTION=(ADDRESS=(PROTOCOL=tcp)(HOST=10.13.13.188)(PORT=1526)))
Listening on: (DESCRIPTION=(ADDRESS=(PROTOCOL=ipc)(KEY=EXTPROC)))

Connecting to (DESCRIPTION=(ADDRESS=(PROTOCOL=TCP)(HOST=10.13.13.188)(PORT=1526)))
TNS-12547: TNS:lost contact
 TNS-12560: TNS:protocol adapter error
  TNS-00517: Lost contact
   Linux Error: 104: Connection reset by peer
Connecting to (DESCRIPTION=(ADDRESS=(PROTOCOL=IPC)(KEY=EXTPROC)))
TNS-12541: TNS:no listener
 TNS-12560: TNS:protocol adapter error
  TNS-00511: No listener
   Linux Error: 111: Connection refused

后来发现  /etc/hosts  中的 127.0.0.1  对应的不是localhost 而是实际的主机名称，如下： 

# Do not remove the following line, or various programs
# that require network functionality will fail.
127.0.0.1            MXB2B-WEB01  
10.13.13.188         MXB2B-WEB01

修改/etc/hosts 为下面的形式 ：  

# Do not remove the following line, or various programs
# that require network functionality will fail.
127.0.0.1         localhost.localdomain   localhost 
10.13.13.188            MXB2B-WEB01

再次开启监听， OK . 

MXB2B-WEB01<*b2b*/home/oracle>$lsnrctl start

LSNRCTL for Linux: Version 10.2.0.4.0 - Production on 09-MAR-2010 13:56:42

Copyright (c) 1991, 2007, Oracle.  All rights reserved.

Starting /u01/product/oracle/bin/tnslsnr: please wait...

TNSLSNR for Linux: Version 10.2.0.4.0 - Production
System parameter file is /u01/product/oracle/network/admin/listener.ora
Log messages written to /u01/product/oracle/network/log/listener.log
Listening on: (DESCRIPTION=(ADDRESS=(PROTOCOL=tcp)(HOST=10.13.13.188)(PORT=1526)))
Listening on: (DESCRIPTION=(ADDRESS=(PROTOCOL=ipc)(KEY=EXTPROC)))

Connecting to (DESCRIPTION=(ADDRESS=(PROTOCOL=TCP)(HOST=10.13.13.188)(PORT=1526)))
STATUS of the LISTENER
------------------------
Alias                     LISTENER
Version                   TNSLSNR for Linux: Version 10.2.0.4.0 - Production
Start Date                09-MAR-2010 13:56:44
Uptime                    0 days 0 hr. 0 min. 0 sec
Trace Level               off
Security                  ON: Local OS Authentication
SNMP                      OFF
Listener Parameter File   /u01/product/oracle/network/admin/listener.ora
Listener Log File         /u01/product/oracle/network/log/listener.log
Listening Endpoints Summary...
  (DESCRIPTION=(ADDRESS=(PROTOCOL=tcp)(HOST=10.13.13.188)(PORT=1526)))
  (DESCRIPTION=(ADDRESS=(PROTOCOL=ipc)(KEY=EXTPROC)))
Services Summary...
Service "PLSExtProc" has 1 instance(s).
  Instance "PLSExtProc", status UNKNOWN, has 1 handler(s) for this service...
Service "b2b" has 1 instance(s).
  Instance "b2b", status UNKNOWN, has 1 handler(s) for this service...
The command completed successfully